Microdosing TRT The Future of Testosterone Replacement Therapy

However it serves as an invaluable way of demonstrating what protocols and drugs suit a person best. We can plot all of this information onto a graph by computational means with some linear algebra. Using mathematical modelling techniques for predicting the absorption, distribution, metabolism and excretion of synthetic or natural chemical substances in our bodies, we can create pharmacokinetic models. Often the output will be in a graph format, as we are showing what the body is doing to a drug over time. There is typically an element of mental discord (ranging from minor to severe), troublesome lethargy, a decline in cognitive function often described as ‘brain fog’, and low libido.

• Whilst a progressive approach may imply an added level of complexity, in fact the contrary applies.
• Ideally, one would use a lower or mid dose cream and apply twice per day until stable levels are met.
• Current prescribing recommendations for the testosterone preparations available are disappointingly out-dated, with the NHS adopting a one-size-fits-all approach to TRT in most instances.

Medicine is a practice; a progressive clinician will continually seek to improve the level of care that they offer to their patient. It is safe to say that times have changed, our understanding of Testosterone Deficiency and TRT has increased exponentially and we have made the necessary adaptations. We have faced numerous challenges along the way, and we are certain that we will face many more. However, we have approached each one as an opportunity to either consolidate, learn, or improve. With that, all of our patients, even those that have been on their TRT journey from the inception of the clinic, are now microdosing, as we are confident that it is the most effective way of achieving stable male androgen levels.

Are Testosterone Injections Fast Acting?

Administration of a medication forces a physiological reaction, even if that medication is “body-identical”, a new buzz term in the healthcare sector. This means it has a subsequent knock on effect on all the parameters that Testosterone, Oestradiol, and DHT influence. It’s role is discussed in detail in ‘TRT, SHBG & Health – Facts, Questions and Evolution‘. Aggressive doses and erratic protocols appear to lower SHBG, which is one of the reasons we are not proponents of using high dose transscrotal testosterone cream.

Our Patient Zero: The Optimal Male & Evolution of Practice at The Men’s Health Clinic

Again, as a point of reference, the average healthy young male produces approximately 6mg of Testosterone per day, with concentrations as high as 10mg per day 11,12. As we’ve said numerous times before, more is not better, both objectively when assessing biomarkers and subjectively, when describing qualitative well-being. In January 2016, we commenced his first trial of TRT with Testosterone Undecanoate, the UK licensed drug for Testosterone Deficiency. This began with an initial saturation dose of 1000mg, followed by a second six-week loading dose of 1000mg, and then follow up doses of 1000mg every 12 weeks. After a suboptimal trough reading of 13.6nmol/l in September 2016, eight months after starting TRT, we made the decision to switch him to a 10-weekly injection interval.

The gel is applied daily, generally in the morning, to the skin; once applied, you shouldn’t swim, shower or get wet for several hours to allow for optimal absorption of testosterone. Although testosterone replacement therapy (TRT) is generally very safe, you should always do comprehensive https://apollo.tn/uk-steroidsonline-uk-com-geranabol-steroids-3/ screening and testosterone tests first. • Sleep — Various studies have indicated that sleeping five or fewer hours a night can reduce testosterone levels. • Fish Oil Supplements — Stress that continues for a long time can cause a rise in cortisol and reduce testosterone production.